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Improving the Halogen-Magnesium Exchange by using New Turbo-Grignard Reagents

Dorothée S Ziegler1, Baosheng Wei1, Paul Knochel1

  • 1Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 20, 2018
PubMed
Summary

The turbo-Grignard reagent accelerates halogen-magnesium exchange reactions, enabling faster synthesis of Grignard reagents. New magnesium reagents also facilitate efficient Br-Mg and Cl-Mg exchange, even in toluene.

Keywords:
Grignard reagenthalogen-magnesium exchangeiodine-zinc exchangelithiummagnesium

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