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Updated: Feb 5, 2026
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
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Global Breast Cancer Research: Moving Forward
Carlos H Barrios1, Tomás Reinert1, Gustavo Werutsky1
1From the Latin American Cooperative Oncology Group, Porto Alegre, Brazil.
Summary
Global breast cancer research faces disparities, particularly in low- and middle-income countries (LMICs). Enhancing access to care and clinical trials in LMICs is crucial for advancing global breast cancer outcomes.
Area of Science:
- Oncology
- Global Health
- Health Disparities
Background:
- Breast cancer is a leading cause of mortality worldwide, with increasing trends in low- and middle-income countries (LMICs).
- Existing global health initiatives address basic needs, but significant disparities in healthcare access, especially for novel therapies, persist.
- Globalization of clinical trials presents both opportunities and challenges for equitable breast cancer research.
Purpose of the Study:
- To review and discuss the multifaceted challenges in global breast cancer research.
- To encourage dialogue aimed at developing actionable strategies to address research disparities.
- To promote advancements in breast cancer care and outcomes worldwide.
Main Methods:
- This review synthesizes current literature and expert discussions on global breast cancer research challenges.
- It examines existing healthcare frameworks, including essential medicines and treatment guidelines.
- The review considers the impact of clinical trial globalization and regional research capacity.
Main Results:
- Significant disparities exist in breast cancer research and treatment access between high-income and LMICs.
- Limited infrastructure and human resources in LMICs hinder the investigation of region-specific breast cancer issues.
- Challenges include increasing trial availability, patient participation, and developing real-world evidence guidelines in LMICs.
Conclusions:
- Addressing global breast cancer research requires targeted strategies to overcome regional disparities.
- International collaboration is vital for building research capacity and infrastructure in LMICs.
- Future efforts must focus on equitable access to clinical trials and evidence-based research to improve global outcomes.
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