Related Experiment Video

Updated: Feb 5, 2026

Simple Continuous Glucose Monitoring in Freely Moving Mice
03:25

Simple Continuous Glucose Monitoring in Freely Moving Mice

Published on: February 24, 2023

7.9K

Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring

Lynn Thomson1,2, Daniela Elleri1,3, Simon Bond3

  • 1Department of Paediatrics, University of Cambridge, Cambridge, UK.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|September 21, 2018
PubMed

Insights

Continuous glucose monitors (CGM) are feasible and safe for preterm infants, improving glucose control and reducing hyperglycemia. This supports their use in future randomized controlled trials for neonatal care.

Area of Science:

  • Neonatal Medicine
  • Endocrinology
  • Medical Devices

Background:

  • Hyperglycemia is frequent in very preterm infants, linked to poor outcomes.
  • Balancing hyperglycemia prevention with hypoglycemia risk is challenging.
  • Continuous glucose monitoring (CGM) offers potential for improved glucose management.

Purpose of the Study:

  • Assess the feasibility and safety of CGM in preterm infants.
  • Inform the design of a future randomized controlled trial (RCT).
  • Evaluate CGM's accuracy and clinical utility for glucose control.

Main Methods:

  • Single-center study in very preterm infants during the first week of life.
  • Accuracy assessed by comparing CGM with blood glucose levels (n=20).
  • Pilot efficacy study (n=20) comparing real-time CGM with standard care (masked CGM).

Main Results:

  • CGM showed good accuracy compared to point-of-care measurements (mean bias -0.27).
  • Increased time in target glucose range (77% vs 59%) and decreased hyperglycemia with CGM.
  • CGM detected unsuspected hypoglycemia; staff found it improved clinical care.

Conclusions:

  • CGM demonstrates sufficient accuracy and utility in preterm infants.
  • The findings support further investigation in a randomized controlled trial.
  • CGM is a promising tool for neonatal glucose management.
Abstract

Keywords:
continuous glucose monitoringglucosehyperglycaemiahypoglycaemia

More Related Videos

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.9K
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.2K

Related Concept Videos

Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.3K
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.5K
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
35.8K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
6.9K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.6K
Pilot and Numeric Relaying01:21

Pilot and Numeric Relaying

Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
492