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Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis

Xiaoyun Gou1,2, Lei Yang1,2, Lingli Pan1,2

  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

BMJ Open
|September 21, 2018
PubMed

Insights

Bronchopulmonary dysplasia (BPD) is a significant risk factor for cerebral palsy (CP) in preterm infants. This meta-analysis confirms a strong association between BPD and the development of CP.

Area of Science:

  • Neonatal research
  • Pediatric neurology
  • Respiratory medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm infants.
  • Cerebral palsy (CP) is a common neurodevelopmental disorder in childhood.
  • The association between BPD and CP requires further investigation.

Purpose of the Study:

  • To conduct a meta-analysis investigating the association between bronchopulmonary dysplasia (BPD) and the risk of cerebral palsy (CP).
  • To synthesize evidence from existing observational studies on BPD and CP risk.

Main Methods:

  • Systematic literature search of EMBASE, PubMed, and Web of Science up to September 2017.
  • Inclusion of observational studies (case-control, cohort) examining the BPD-CP association.
  • Meta-analysis using a random effects model for data synthesis.

Main Results:

  • Eleven studies were included in the meta-analysis.
  • Bronchopulmonary dysplasia (BPD) was significantly associated with an increased risk of cerebral palsy (CP) (ORs 2.10; 95% CI 1.57 to 2.82) in preterm infants.
  • Heterogeneity in results was attributed to study design, BPD definition, CP diagnosis timing, and confounder adjustment.

Conclusions:

  • Bronchopulmonary dysplasia (BPD) is identified as a risk factor for cerebral palsy (CP).
  • Further research is warranted to confirm these findings and explore influencing variables.
Abstract

Keywords:
bronchopulmonary dysplasiacerebral palsyinfantneurodevelopment

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