Related Experiment Video
Updated: Jan 14, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
The Critical Roles of Methyltransferase-Like 3 in Atherosclerosis and Arterial Infarction: Breakthroughs in Mechanism
Ruida Liu1,2, Lei Yang1,3, Dongqiong Xiao1,3
1Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
None:
Atherosclerosis (AS) and arterial infarction currently have a significant impact on human health. Due to their complex pathogenesis and lack of effective treatment approaches, patients worldwide experience high mortality rates. Methyltransferase-like 3 (METTL3)-mediated RNA N6-modification has garnered considerable attention in elucidating the mechanisms underlying the pathogenesis and treatment failure of AS and arterial infarction. However, few reviews have explored the interrelationship between them. Therefore, this review aims to address this literature gap by evaluating all studies reporting on the involvement of METTL3 in AS and arterial infarction, as well as targeting METTL3 for rescuing these diseases. This review suggests that METTL3 serves as a risk factor, diagnostic biomarker and therapeutic target for AS and arterial infarction. Overall, it provides a comprehensive overview of cutting-edge research on METTL3 in AS and arterial infarction, serving as a convenient reference for researchers in both basic and translational medicine fields.
More Related Videos
05:35Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model
Published on: August 25, 2020
11:00A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
Published on: June 22, 2010
Related Concept Videos
Atherosclerosis I: Introduction
Atherosclerosis III: Management
Coronary Artery Disease II: Pathophysiology
Inflammation
Coronary Artery Disease I: Introduction