Pharmaceutical Intervention of Aging

Area of Science:

• Gerontology and Molecular Biology
• Biomedical Sciences

Background:

• Aging is a major risk factor for numerous diseases, posing a global socioeconomic challenge.
• Interventions targeting aging itself may be more effective for disease prevention than disease-specific treatments.

Purpose of the Study:

• To review the latest findings on molecular compounds that target aging pathways.
• To explore interventions mimicking caloric restriction, boosting NAD+ levels, and eliminating senescent cells.

Main Methods:

• Review of recent scientific literature on anti-aging molecular compounds.
• Focus on compounds like metformin, resveratrol, spermidine, rapamycin, NAD+ boosters, and senolytics.
• Analysis of how these compounds modulate key aging pathways (TOR, AMPK, sirtuins, IGF-1).

Main Results:

• Several molecular compounds show potential in modulating aging determinants.
• Interventions discussed target fundamental aging processes, not just individual diseases.
• These compounds influence critical signaling pathways linked to longevity and age-related diseases.

Conclusions:

• Pharmacological targeting of aging mechanisms is a viable strategy for preventing age-related disorders.
• Compounds mimicking caloric restriction, enhancing NAD+ bioavailability, and senolytics represent key areas of research.
• Modulating pathways like AMPK, TOR, sirtuins, and IGF-1 is central to these anti-aging interventions.