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Related Concept Videos

Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

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As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
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Nursing Interventions I: Taxonomy of Nursing Interventions01:03

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Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
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Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
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Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
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Pharmaceutical Intervention of Aging.

Minxian Qian1, Baohua Liu2

  • 1Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Medical Research Center, Department of Biochemistry and Molecular Biology, Shenzhen University Health Science Center, Shenzhen, China.

Advances in Experimental Medicine and Biology
|September 21, 2018
PubMed
Summary

Targeting the aging process with compounds that mimic caloric restriction, boost NAD+ levels, or clear senescent cells offers a promising strategy for preventing age-related diseases.

Keywords:
Age-related diseasesAgingPharmaceutical intervention

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Area of Science:

  • Gerontology and Molecular Biology
  • Biomedical Sciences

Background:

  • Aging is a major risk factor for numerous diseases, posing a global socioeconomic challenge.
  • Interventions targeting aging itself may be more effective for disease prevention than disease-specific treatments.

Purpose of the Study:

  • To review the latest findings on molecular compounds that target aging pathways.
  • To explore interventions mimicking caloric restriction, boosting NAD+ levels, and eliminating senescent cells.

Main Methods:

  • Review of recent scientific literature on anti-aging molecular compounds.
  • Focus on compounds like metformin, resveratrol, spermidine, rapamycin, NAD+ boosters, and senolytics.
  • Analysis of how these compounds modulate key aging pathways (TOR, AMPK, sirtuins, IGF-1).

Main Results:

  • Several molecular compounds show potential in modulating aging determinants.
  • Interventions discussed target fundamental aging processes, not just individual diseases.
  • These compounds influence critical signaling pathways linked to longevity and age-related diseases.

Conclusions:

  • Pharmacological targeting of aging mechanisms is a viable strategy for preventing age-related disorders.
  • Compounds mimicking caloric restriction, enhancing NAD+ bioavailability, and senolytics represent key areas of research.
  • Modulating pathways like AMPK, TOR, sirtuins, and IGF-1 is central to these anti-aging interventions.