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Total Synthesis of Asperphenins A and B
Jia-Lei Yan1, Yingying Cheng1, Jing Chen1
1State Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen 518055 , China.
Abstract:
The first total synthesis of asperphenins A and B has been accomplished in a concise, highly stereoselective fashion from commercially available materials (15 steps, 9.7% and 14.2% overall yields, respectively). The convergent route featured the judicious choice of protecting groups, fragment assembly strategy and a late-stage iron-catalyzed Wacker-type selective oxidation of an internal alkene to the corresponding ketone.
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