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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Published on: February 7, 2019

Exploring NiCl2, PdCl2 and PtCl2 as a catalyst for [3 + 2] cycloaddition in Kopsane alkaloid synthesis by density

Sanghee Yoon1, Pratanphorn Nakliang1, Bilal Shaker1

  • 1Global AI Drug Discovery Center, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea.

Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents
|July 14, 2026
PubMed
Summary

Density functional theory (DFT) explored nickel, palladium, and platinum catalysts for Kopsane alkaloid synthesis. Nickel catalysts show promise for efficient and selective synthesis, offering a sustainable alternative to platinum.

Keywords:
Catalyst designDensity functional theoryKopsane alkaloidsOrganic synthesis

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