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Updated: Feb 5, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Problem-Solving in Patients with Targeted Drug Delivery Systems.
1Rez Farid, MD, is Associate Professor of Clinical PM&R, Department of Physical Medicine and Rehabilitation, University of Missouri Health Care.
Physicians can manage concerns about intrathecal drug delivery systems in after-hours care. Pump malfunctions are rare, and resources like algorithms and manufacturer support are available for patient care.
Area of Science:
- Pain Management
- Neurosurgery
- Pharmacology
Background:
- Intrathecal drug delivery systems are used for chronic pain management.
- Patients with these systems often present to emergency rooms with concerns about device function.
- Physicians may lack experience with these specialized devices, causing anxiety.
Purpose of the Study:
- To provide guidance for physicians managing patients with intrathecal drug delivery systems during after-hours care.
- To address the common concern of "my pump isn't working" in emergency settings.
- To highlight the rarity of actual pump malfunctions and available resources.
Main Methods:
- Review of common patient complaints related to intrathecal pumps.
- Identification of available resources for physician support.
- Discussion of algorithms for managing potential drug under- or over-infusion.
Main Results:
- Intrathecal pump malfunctions are infrequent.
- Physicians can be prepared to manage patient concerns effectively.
- Manufacturer technical support and clinical algorithms are valuable resources.
Conclusions:
- With appropriate resources, physicians can confidently manage patients with intrathecal drug delivery systems.
- Preparedness reduces physician anxiety and ensures appropriate patient care.
- Emphasis on rare malfunctions and available support systems is crucial.
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