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Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Synthetic Antigen Controls for Immunohistochemistry

Synthetic Antigen Controls for Immunohistochemistry

Published on: August 23, 2021

Eicosanoid Control Over Antigen Presenting Cells in Asthma.

Nincy Debeuf^1,2, Bart N Lambrecht^1,2,3

¹Laboratory of Immunoregulation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Frontiers in Immunology

|September 21, 2018

Summary

This summary is machine-generated.

Eicosanoids, including prostaglandins and leukotrienes, significantly impact immune cells like dendritic cells and macrophages in asthma. This influences T cell responses and contributes to allergic asthma development.

Keywords:

asthma dendritic cells eicosanoids leukotrienes macrophages prostaglandins

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Area of Science:

Immunology
Respiratory Medicine

Background:

Asthma affects 300 million globally, with allergic asthma characterized by Th2/Th17 cell responses.
Immune responses involve CD4+ T helper cells, innate lymphoid cells (ILC2), and myeloid cells like dendritic cells (DCs) and macrophages.

Purpose of the Study:

To review the role of eicosanoids in modulating DC and macrophage function in asthma.
To elucidate how eicosanoid-mediated immune cell changes drive aberrant T cell differentiation and disease.

Main Methods:

Literature review focusing on eicosanoid pathways in asthma immunology.
Analysis of the interplay between lipid mediators, myeloid cells, and adaptive/innate immune cells.

Main Results:

Eicosanoids (prostaglandins, leukotrienes) exert diverse effects on DC and macrophage functions.
These lipid mediators influence T cell (Th2, Th17) differentiation and innate immune responses (ILC2).

Conclusions:

Eicosanoids are critical regulators of immune cell activity in the asthmatic lung.
Dysregulation of eicosanoid pathways contributes to the pathogenesis of various asthma subtypes.