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Marine Actinomycetes with Probiotic Potential and Bioactivity against Multidrug-resistant Bacteria
Hamed Norouzi1, Abolghasem Danesh2, Mojtaba Mohseni3
1Department of Biology, University of Isfahan, Isfahan, Iran.
International Journal of Molecular and Cellular Medicine
|September 21, 2018
Summary
Marine actinomycetes from the Caspian Sea yield novel antimicrobial compounds effective against multi-drug resistant pathogens like MRSA and VRE. These promising strains also exhibit anti-vibrio activity and produce useful exoenzymes.
Area of Science:
- Marine Microbiology
- Antimicrobial Resistance
- Natural Product Discovery
Background:
- The escalating problem of antimicrobial resistance necessitates the discovery of new bioactive compounds.
- Marine microorganisms, particularly actinomycetes, are a rich source of novel bioactive natural products.
- Caspian Sea actinomycetes represent an underexplored reservoir for potential antimicrobial agents.
Purpose of the Study:
- To screen marine actinomycetes from the Caspian Sea for antimicrobial activity against multi-drug resistant (MDR) pathogens.
- To identify potent strains and characterize their bioactive compounds.
- To evaluate the anti-vibrio activity and exoenzymatic potential of the selected isolates.
Main Methods:
- Isolation and screening of 21 marine actinomycetes from Caspian Sea sediments.
- Morphological characterization and genetic identification using 16S rRNA gene sequencing.
- Antimicrobial activity testing via cross-streak and disc diffusion methods against MDR bacteria.
- Evaluation of anti-vibrio activity and exoenzyme (amylase, protease) production.
Main Results:
- Three actinomycete strains (MN2, MN39, MN40) exhibited broad-spectrum antimicrobial activity.
- 16S rRNA analysis identified the potent strains as belonging to the genus *Streptomyces*.
- Ethyl acetate extracts from MN2 and MN39 showed significant antibacterial activity against methicillin-resistant *Staphylococcus aureus* (MRSA) and vancomycin-resistant *Enterococcus* (VRE).
- All potent strains displayed notable anti-vibrio activity and produced extracellular amylase and protease.
Conclusions:
- Marine actinomycetes from the Caspian Sea sediments produce bioactive compounds effective against critical MDR pathogens.
- The identified *Streptomyces* isolates (MN2, MN39) are promising sources for novel antibacterial agents.
- These strains warrant further investigation as potential probiotics due to their combined anti-vibrio activity and exoenzyme production.
Keywords:
Caspian SeaMarine actinomycetesanti-vibrioantimicrobial activitymulti-drug resistant bacteriaMore Related Videos
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