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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
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Evaluation of Pharmacy-Developed Antibiotic Desensitization Protocols
Xian Jie Cindy Chen1, Karen Fong1, Diana Altshuler1
11 NYU Langone Health, New York, NY, USA.
The Annals of Pharmacotherapy
|September 21, 2018
Summary
Pharmacy-developed antibiotic desensitization protocols are safe and effective. These protocols demonstrate high success rates in patients requiring antibiotic desensitization, with most cases completed without adverse reactions.
Area of Science:
- Clinical Pharmacy
- Pharmacology
- Infectious Diseases
Background:
- Optimizing antibiotic administration parameters is crucial for successful desensitization.
- Individualized pharmacokinetic considerations enhance antibiotic desensitization success.
Purpose of the Study:
- Evaluate the success and safety of institutional pharmacy-developed antibiotic desensitization protocols.
- Assess the efficacy of standardized antibiotic desensitization procedures.
Main Methods:
- Retrospective study at an 800-bed academic medical center.
- Included 36 adult patients in intensive care units undergoing antibiotic desensitization.
- Utilized pharmacy-developed desensitization protocols.
Main Results:
- 61 desensitization cases were analyzed.
- 97% of desensitizations were completed successfully.
- 89% of successful cases had no reactions; 10% experienced manageable reactions.
Conclusions:
- Pharmacy-developed antibiotic desensitization protocols are safe and effective.
- These protocols can be successfully adapted by other institutions.
- Successful antibiotic desensitization can be achieved with optimized protocols.
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