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Reproducibility of quantitative flow ratio: An inter-core laboratory variability study.
Yunxiao Chang1, Liwei Chen2, Jelmer Westra3
1Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Cardiology Journal
|September 21, 2018
Summary
Quantitative flow ratio (QFR) demonstrated good reproducibility between independent core laboratories for assessing coronary stenosis. Standardized conditions are crucial for reliable QFR analysis in clinical practice.
Area of Science:
- Cardiology
- Medical Imaging
- Interventional Cardiology
Background:
- Quantitative flow ratio (QFR) is an emerging method to determine fractional flow reserve (FFR) from coronary angiography.
- Evaluating the reproducibility of QFR across different analytical centers is essential for its clinical adoption.
Purpose of the Study:
- To assess the inter-core laboratory reproducibility of QFR analysis.
- To determine if QFR can be reliably computed by independent centers using standardized protocols.
Main Methods:
- Two independent core laboratories analyzed coronary angiograms from the FAVOR II China Study.
- Quantitative flow ratio (QFR) was computed using the AngioPlus system following identical standard operating procedures.
- Analysts were blinded to fractional flow reserve (FFR) and online QFR values.
Main Results:
- QFR was successfully obtained in 328 of 332 interrogated vessels.
- Excellent diagnostic accuracy was observed, with areas under the curve of 0.970 and 0.963 for the two core laboratories, respectively, when compared to FFR.
- Mean differences in QFR between the two core laboratories were minimal (0.004 ± 0.03), indicating high reproducibility.
Conclusions:
- Quantitative flow ratio (QFR) analysis exhibits good reproducibility between independent core laboratories.
- Standardized conditions are imperative for consistent and reliable QFR assessments in clinical settings.
Keywords:
core laboratoriescoronary stenosisfractional flow reservequantitative flow ratioreproducibilityMore Related Videos
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