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[Tissue Intrinsic Fluorescence Spectrum Recovering Based on Diffusion Theory].

Yong Liu, Yuan-zhi Zhang, Hua-yi Hou

    Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
    |September 21, 2018
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    Summary
    This summary is machine-generated.

    A new fiber-optic probe system recovers intrinsic fluorescence from skin, improving diabetes mellitus prediction. Recovered intrinsic fluorescence shows 90% sensitivity for screening diabetes, outperforming standard measurements.

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    Area of Science:

    • Biomedical Optics
    • Medical Diagnostics
    • Biochemical Analysis

    Background:

    • Tissue absorption and scattering impair fluorescence spectrum analysis.
    • Accurate tissue biochemical properties are crucial for diagnostics.
    • Existing methods struggle to isolate intrinsic fluorescence signals.

    Purpose of the Study:

    • To develop a system for measuring intrinsic fluorescence spectrum.
    • To extract physiological parameters from diffuse reflectance.
    • To predict diabetes mellitus probability using recovered skin intrinsic fluorescence.

    Main Methods:

    • Developed a fiber-optic probe system for simultaneous fluorescence and diffuse reflectance measurements.
    • Applied diffusion theory to extract physiological parameters (blood volume, oxygen saturation, melanin, scattering).
    • Calculated optical parameters and recovered intrinsic fluorescence spectrum from measured data.

    Main Results:

    • Clinical trials demonstrated successful recovery of intrinsic skin fluorescence.
    • Recovered intrinsic fluorescence achieved 90% sensitivity for diabetes screening at 75% specificity.
    • Standard fluorescence measurement showed only 69% sensitivity for diabetes screening.

    Conclusions:

    • The developed system effectively recovers intrinsic fluorescence spectra.
    • Recovered intrinsic fluorescence significantly enhances diabetes mellitus prediction accuracy.
    • This technique offers a promising non-invasive method for diabetes screening.