Related Experiment Video

Updated: Feb 5, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

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Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

Ewa Ksiezopolska1,2, Toni Gabaldón3,4,5

  • 1Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), 08003 Barcelona, Spain. ewa.ksiezopolska@crg.eu.

Genes
|September 22, 2018
PubMed

Insights

Drug resistance in Candida fungal infections is a growing concern. This review explores the evolutionary genomics of antifungal resistance in Candida, highlighting genetic factors and future research directions.

Area of Science:

  • Medical Mycology
  • Evolutionary Biology
  • Genomics

Background:

  • Fungal infections, particularly candidiasis, are increasing due to a growing population of immunocompromised individuals.
  • Current antifungal treatments face challenges from emerging drug-resistant Candida strains.
  • Limited research exists on the evolutionary mechanisms driving fungal drug resistance compared to bacterial antibiotic resistance.

Purpose of the Study:

  • To review the genetic underpinnings of antifungal drug resistance in Candida opportunistic pathogens.
  • To examine the evolutionary pathways leading to the emergence and selection of resistant Candida phenotypes.
  • To discuss the future of antifungal resistance research using advanced technologies.

Main Methods:

  • Literature review focusing on evolutionary genomics.
  • Analysis of genetic bases for drug resistance in Candida species.
  • Discussion of in vitro evolution and clinical isolate studies.

Main Results:

  • Identifies key genetic factors contributing to antifungal resistance in Candida.
  • Elucidates potential evolutionary trajectories for resistance development.
  • Highlights the need for further investigation into resistance mechanisms.

Conclusions:

  • Understanding the evolution of antifungal resistance is crucial for developing new therapies.
  • Genomic approaches offer powerful tools to study resistance evolution in Candida.
  • Future research should integrate diverse methodologies to combat rising resistance.
Keywords:
Candidaantifungal drugsdrug resistanceevolution

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