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Association Between Alcohol Intake and Cardiac Remodeling
Patrícia Rodrigues1, Samuel Santos-Ribeiro2, Tiago Teodoro3
1Cardiology Department, Barts Heart Center, London, United Kingdom (when this work was initiated); Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
Journal of the American College of Cardiology
|September 22, 2018
Summary
Long-term alcohol consumption in young adults is linked to adverse cardiac remodeling, specifically increased left ventricular mass and volume. Wine consumption showed a protective effect, while binge drinking trended towards harm.
Area of Science:
- Cardiology
- Cardiovascular Research
- Public Health
Background:
- Alcohol-induced cardiotoxicity mechanisms and long-term effects on young adults are not fully understood.
- The impact of alcohol on ventricular remodeling, dysfunction, and consumption thresholds remains controversial.
Purpose of the Study:
- To investigate the relationship between alcohol intake and cardiac remodeling over 20 years.
- To assess the association between drinking habits and echocardiographic outcomes in young adults.
Main Methods:
- Analysis of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort.
- Echocardiographic assessment of left ventricular (LV) structure and function at baseline and 25 years.
- Evaluation of alcohol consumption via weighted-average weekly intake and cumulative consumption.
Main Results:
- Alcohol consumption independently predicted increased indexed LV mass and LV end-diastolic volume.
- No significant association was found between alcohol intake and LV ejection fraction.
- Drinking predominantly wine was linked to less cardiac remodeling; binge drinking showed a trend towards harm.
Conclusions:
- Alcohol intake is associated with adverse cardiac remodeling in initially healthy young adults over 20 years.
- Alcohol consumption did not correlate with LV systolic dysfunction in this cohort.
- Wine consumption may offer a protective effect against alcohol-related cardiac structural changes.
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