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Updated: Feb 5, 2026

Organotypic Cultures of Adult Human Cortex as an Ex vivo Model for Human Stem Cell Transplantation and Validation
Published on: December 9, 2022
Modelling the Human Cortex in Three Dimensions
Esther Kuehn1, Martin I Sereno2
1Aging and Cognition Research Group, DZNE, Magdeburg, 39106, Germany; Center for Behavioral Brain Sciences Magdeburg, Magdeburg, 39106, Germany; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, 04103, Germany.
Abstract:
In cognitive neuroscience, brain-behaviour relationships are usually mapped onto a 2D cortical sheet. Cortical layers are a critical but often ignored third dimension of human cortical function. Improved resolution has put us on the threshold of beginning to image human cognition in three dimensions.
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