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Related Experiment Video

Updated: Feb 5, 2026

In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses

In Situ Microscopy for Real-time Determination of Single-cell Morphology in Bioprocesses

Published on: December 5, 2019

Microfluidics for cell factory and bioprocess development.

Sara M Bjork¹, Haakan N Joensson¹

¹Division of Protein Science, School of Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Sweden.

Current Opinion in Biotechnology

|September 22, 2018

Summary

Microfluidic tools accelerate bioindustry innovation by enabling rapid development of cell factories and bioprocesses. These technologies enhance throughput and automation for faster product development.

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Area of Science:

Biotechnology
Bioprocess Engineering
Synthetic Biology

Background:

The bioindustry requires rapid development of cell factories and bioprocesses for diverse products.
Traditional development cycles can be lengthy and resource-intensive.

Purpose of the Study:

To highlight the role of microfluidic tools in accelerating cell factory and bioprocess development.
To showcase recent advancements and applications of microfluidics in the bioindustry.

Main Methods:

Integration of microfluidic devices with synthetic biology and metabolic modeling.
Development of microfluidic tools for DNA assembly, transformation, and high-throughput screening.
Utilization of micron-scale bioreactors for bioprocess optimization.

Main Results:

Microfluidics enables integrated DNA assembly and transformation.
High-throughput screening of cell factory libraries is facilitated by microfluidic platforms.
Microfluidic bioreactors allow for efficient process optimization.

Conclusions:

Microfluidic tools significantly enhance the biotechnological engineering cycle.
Increased throughput, parallelization, and automation are key benefits.
Microfluidics is crucial for the rapid development of novel bioindustry products.