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Updated: Feb 5, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
Published on: January 8, 2015
Expansion of the metazoan virosphere: progress, pitfalls, and prospects
1Institute of Evolutionary Biology, and Centre for Immunity, Infection and Evolution, The University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, United Kingdom.
Abstract:
Metagenomic sequencing has led to a recent and rapid expansion of the animal virome. It has uncovered a multitude of new virus lineages from under-sampled host groups, including many that break up long branches in the virus tree, and many that display unexpected genome sizes and structures. Although there are challenges to inferring the existence of a virus from a `virus-like sequence', in the absence of an isolate the analysis of nucleic acid (including small RNAs) and sequence data can provide considerable confidence. As a consequence, this period of molecular natural history is helping to reshape our views of deep virus evolution.
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