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Benjamin Chaucer1, Abriella Stone1, Dustin Whelan1

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Acute Generalized Exanthematous Pustulosis (AGEP) is a rare skin reaction. This case highlights ibuprofen use following a dog bite as a potential, uncommon cause of AGEP.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Toxicology

Background:

  • Acute Generalized Exanthematous Pustulosis (AGEP) is a rare drug-induced hypersensitivity reaction.
  • AGEP typically presents with fever, leukocytosis, and a widespread pustular rash.
  • While commonly linked to antibiotics, various drugs and stimuli have been implicated.

Purpose of the Study:

  • To report a rare case of AGEP.
  • To investigate a unique trigger for AGEP.
  • To enhance clinical awareness of AGEP etiologies.

Main Methods:

  • Case report presentation.
  • Literature review of ibuprofen- and dog bite-associated AGEP.
  • Clinical and diagnostic assessment of a patient presenting with AGEP symptoms.

Main Results:

  • A 46-year-old female developed AGEP after self-medicating with ibuprofen for a dog bite.
  • Literature search identified only four prior cases of ibuprofen-associated AGEP and one dog bite-associated AGEP.
  • The presented case combines both triggers, representing a rare clinical scenario.

Conclusions:

  • This case underscores the importance of considering non-antibiotic triggers for AGEP.
  • Identifying the causative agent in AGEP can be diagnostically challenging.
  • Practitioners should be aware of this rare ibuprofen and dog bite-associated AGEP presentation.