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IL-4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes

Lei Bao1, Cecilia Chau2, Jeremy Bao1

  • 1Department of Dermatology, University of Illinois, 808 S Wood St., Chicago, Illinois 60612, USA.

Microbiology and Immunology
|September 22, 2018
PubMed

Insights

Interleukin-4 (IL-4) dysregulates microRNAs in atopic dermatitis (AD), impacting inflammation and cell death pathways. These microRNAs offer potential therapeutic targets for AD treatment.

Area of Science:

  • Immunology
  • Molecular Biology
  • Dermatology

Background:

  • Interleukin-4 (IL-4) is a key cytokine in atopic dermatitis (AD) pathogenesis.
  • IL-4 influences gene expression at the transcriptional level in AD.

Purpose of the Study:

  • To investigate the role of IL-4 in microRNA (miRNA) dysregulation in AD.
  • To identify specific miRNAs affected by IL-4 in AD pathogenesis.

Main Methods:

  • Utilized a microRNA array technique.
  • Employed IL-4 transgenic mouse models.

Main Results:

  • IL-4 dysregulated 27 common miRNAs, with 26 upregulated and 1 downregulated.
  • Significantly upregulated miRNAs include miR-101-5p, miR-122-5p, miR-142-3p, miR-204-5p, miR-335-3p, miR-376a-3p, miR-378a-5p, miR-639, and miR-9-5p.
  • Downregulated miRNA, miR-147a, attenuates TLR-induced inflammatory responses.

Conclusions:

  • Dysregulated miRNAs identified in this study may post-transcriptionally regulate key genes in AD.
  • These findings suggest potential miRNA-based therapeutic strategies for atopic dermatitis.
Keywords:
IL-4atopic dermatitiskeratinocytesmicroRNA

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