Primary angle closure and primary angle closure glaucoma in retinal vein occlusion

Area of Science:

• Ophthalmology
• Glaucoma Research
• Vascular Retinal Diseases

Background:

• Retinal vein occlusion (RVO) is a significant cause of vision loss.
• Primary angle closure (PAC) and primary angle closure glaucoma (PACG) are prevalent forms of glaucoma, particularly in East Asian populations.
• The relationship between RVO and angle-closure disorders remains incompletely understood.

Purpose of the Study:

• To determine the frequency of PAC and PACG in patients diagnosed with RVO.
• To analyze the prevalence of PAC/PACG across different subtypes of RVO.
• To investigate potential associations between angle-closure and RVO in a hospital-based cohort.

Main Methods:

• Retrospective review of 375 consecutive patients newly diagnosed with RVO.
• Diagnostic methods included fluorescein fundus angiography and gonioscopy.
• RVO and glaucoma classifications followed established international criteria.

Main Results:

• The overall frequency of PACG in RVO patients was 4.1%.
• PACG prevalence varied by RVO type: 5.3% in CRVO, 8.8% in HRVO, and 1.9% in BRVO.
• PAC/PACG was significantly more frequent in NONHS-RVO (18.9%) compared to other RVO subtypes.

Conclusions:

• The prevalence of PAC/PACG is notably higher in RVO patients than in the general population.
• Mechanical changes in the optic disc lamina cribrosa associated with PAC/PACG may contribute to RVO development.
• Angle-closure conditions should be considered in the clinical evaluation of Chinese patients presenting with RVO.