Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What's next in using CT scans to better understand cachexia?

Sami Antoun1, Caroline Rossoni2, Emilie Lanoy2,3

  • 1Emergency Unit.

Current Opinion in Supportive and Palliative Care
|September 22, 2018
PubMed
Summary

Cachexia (CAX) assessment using CT scans of skeletal muscle mass (SMM) faces barriers in routine clinical use. Research aims to develop better CAX staging and understand mechanisms for improved patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neighborhood Satisfaction and Smoking in France: A Cross-Sectional Analysis.

Substance use & misuse·2026
Same author

Cemiplimab versus historical systemic treatments for locally advanced or metastatic cutaneous squamous cell carcinomas: Results from the French study TOSCA.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Weight Variations during First-Line Systemic Treatment of Metastatic Non-Small Cell Lung Cancer: New Paradigms from Real-World Data.

Oncology·2026
Same author

Association between late access to care and mortality for PWH: insights from the French Hospital Database on HIV (ANRS CO4-FHDH) from 2002 to 2016.

BMJ public health·2025
Same author

Reliability of minimally trained operator's left ventricular outflow tract velocity-time integral measurement guided by artificial intelligence: protocol for a multicentre randomised controlled trial.

BMJ open·2025
Same author

Evaluation of Methods for Joinpoint Analysis of Time Series Using Simulated and Real-World Data.

Journal of clinical epidemiology·2025

Area of Science:

  • Oncology
  • Metabolism
  • Radiology

Background:

  • Cachexia (CAX) is a protein metabolism disorder linked to cancer, impacting patient prognosis.
  • Computed tomography (CT) scans assessing skeletal muscle mass (SMM) are crucial for evaluating CAX.
  • Current CAX biomarkers lack strong outcome association and clinical utility.

Purpose of the Study:

  • Analyze barriers to routine CT-based SMM assessment for CAX risk stratification.
  • Propose research directions for a deeper understanding of CAX mechanisms.
  • Establish a standardized, clinically relevant CAX staging system.

Main Methods:

  • Review of current literature on CT-based skeletal muscle mass assessment in cachexia.
  • Analysis of existing CAX staging systems and biomarkers.

Related Experiment Videos

  • Identification of challenges in integrating SMM measurements into routine clinical practice.

    • Main Results:

    • Existing CAX biomarkers show limited association with patient outcomes.
    • Multidimensional CAX signatures integrating inflammatory markers and nutritional assessments are complex.
    • Barriers exist in standardizing SMM definitions and their clinical application.

    Conclusions:

    • Standardized sarcopenia definitions and prospective studies are needed for clinical validation.
    • SMM loss can indicate early protein disorders, potentially triggering nutritional support.
    • Tracking SMM changes aids in understanding CAX mechanisms and tumor evolution.