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Published on: October 11, 2013
Mannoside Glycolipid Conjugates Display Antiviral Activity Against Ebola Virus
Olivier Reynard1, Evelyne Schaeffer2, Valentina A Volchkova1
1Laboratory Molecular Basis of Viral Pathogenicity, Centre International de Recherche en Infectiologie, INSERM, University of Lyon, Université Claude Bernard Lyon, ENS de Lyon, CNRS, UMR, Lyon, France.
Abstract:
The West African outbreak of Ebola virus (EBOV) infection during 2013-2016 highlighted the need for development of field-applicable therapeutic drugs for this infection. Here we report that mannoside glycolipid conjugates (MGCs) consisting of a trimannose head and a lipophilic chain assembled by a linker inhibit EBOV infection not only of human monocyte-derived dendritic cells and macrophages, but also of a number of susceptible cells. Analysis of the mode of action leads us to conclude that MGCs act directly on cells, notably by preventing virus endocytosis.
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