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Updated: Feb 5, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Neutrophils in tPA-induced hemorrhagic transformations: Main culprit, accomplice or innocent bystander?
Thavarak Ouk1, Camille Potey1, Ilaria Maestrini2
1University of Lille, Inserm, CHU Lille, U1171 - Degenerative and vascular cognitive disorders, F-59000 Lille, France; University of Lille, CHU Lille, Département de Pharmacologie, F-59000 Lille, France.
Abstract:
The risk of intracerebral hemorrhage still greatly limits the use of tPA in stroke patients. Research is ongoing in order to identify the pathophysiological mechanisms at play, detect predictive biomarkers and discover new pharmacological targets to develop preventive or curative treatments. Going through experimental and clinical studies, this review focuses on the role of neutrophils as key predictive biomarkers for thrombolysis-induced hemorrhages and as pharmacological targets to limit their occurrence. To date, there are no established pharmacological modulators of neutrophils for ischemic stroke and its hemorrhagic complications. Several strategies are under evaluation, including lipid-lowering drugs, free radical scavengers, or minocycline, as well as non-pharmacological interventions such as physical exercise.
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