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A combined mathematical model linking the formation of amorphous solid dispersions with hot-melt-extrusion process

A Schittny1, H Ogawa2, J Huwyler3

  • 1Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Switzerland; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Switzerland.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|September 22, 2018
PubMed

Keywords:
Amorphous solid dispersionBioavailabilityFormulation developmentHot-melt extrusionPoorly water-soluble drugsProcess modeling

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