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Adherence of Bacteria to Plant Surfaces Measured in the Laboratory
Published on: June 19, 2018
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Variation in Adherence Measures to Imatinib Therapy.
Uday Yanamandra1, Pankaj Malhotra1, K K Sahu1
1Uday Yanamandra, Pankaj Malhotra, K.K. Sahu, Neha Saini, Pooja Chauhan, Jasmeen Gill, Deepika Rikhi, Alka Khadwal, Gaurav Prakash, Deepesh Lad, Vikas Suri, Savita Kumari, Neelam Varma, and Subhash Varma, Postgraduate Institute of Medical Education and Research, Chandigarh; and Yanamandra Sushma, Max Hospital, Mohali, Punjab, India.
Journal of Global Oncology
|September 23, 2018
Summary
Patient adherence to tyrosine kinase inhibitor therapy for chronic myeloid leukemia is crucial for treatment success. This study in resource-constrained settings found that adherence, particularly when assessed by physicians, significantly correlates with molecular response, highlighting the need for targeted interventions.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Tyrosine kinase inhibitors (TKIs) have revolutionized chronic myeloid leukemia (CML) treatment, leading to improved survival rates.
- Adherence to TKI therapy remains a significant challenge in managing CML, impacting long-term patient outcomes.
- Understanding adherence factors in resource-constrained settings is vital for public health initiatives.
Purpose of the Study:
- To investigate adherence to TKI therapy among CML patients in a resource-constrained setting.
- To identify factors contributing to nonadherence in this population.
- To correlate adherence levels with current molecular response status.
Main Methods:
- A single-center, cross-sectional, observational study was conducted in North India.
- A questionnaire-based survey using the Modified Morisky Adherence Scale (MMAS-9) and physician assessment was employed.
- Statistical analysis, including logistic regression, was performed to evaluate adherence and its correlates.
Main Results:
- Out of 333 patients, adherence was 54.95% by MMAS-9 and 90.39% by physician assessment, with no correlation between the two methods.
- A significant relationship was observed between major molecular response and adherence by both MMAS-9 and physician assessment (P < .001).
- Enrollment in a patient assistance program (Novartis Oncology Access) was significantly associated with higher adherence (P = .012).
Conclusions:
- Real-world adherence to TKI therapy in CML can be suboptimal, necessitating targeted interventions.
- Physician assessment appears to overestimate adherence compared to patient-reported measures like MMAS-9.
- Adherence is strongly linked to molecular response, underscoring its clinical importance and the need for support programs.
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