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Updated: Feb 5, 2026

High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT
Published on: June 21, 2011
Investigation on the resolution of a micro cone beam CT scanner scintillating detector using Monte Carlo methods
W Volken1, M A Zulliger2, B Koller2
1Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Abstract:
The impact of several physical quantities on the spatial resolution of an X-ray scintillating pixel detector for a micro cone beam CT (µCBCT) is investigated and discussed. The XtremeCT from SCANCO Medical AG was simulated using the EGSnrc/EGS++ Monte Carlo (MC) framework and extensively benchmarked in a previous work. The resolution of the detector was determined by simulating a titanium knife-edge to obtain the edge spread function (ESF) and the modulation transfer function (MTF). Propagation of the scintillation light through the scintillator and its coupling into the fiber optics system was taken into account. The contribution of particles scattered in the main scanner components to the detector signal is very low and does not affect the spatial resolution of the detector. The resolution obtained from the energy deposition in the scintillator without any blurring due to the propagation of the scintillation light into the fiber optics array was 31 µm. By assuming isotropic light propagation in the scintillator, the resolution degraded to 360 µm. A simple light propagation model taking into account the impact of the scintillator's columnar microstructures was developed and compared with the MANTIS Monte Carlo simulation package. By reducing the width of the model's light propagation kernel by a factor of 2 compared to the isotropic case, the detector resolution can be improved to 83 µm, which corresponds well to the measured resolution of 86 µm. The resolution of the detector is limited mainly by the propagation of the scintillation light through the scintillator layer. It offers the greatest potential to improve the resolution of the µCBCT imaging system.
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