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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Potential targets for the development of new antifungal drugs

Hao Su1, Li Han2, Xueshi Huang3

  • 1Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.

The Journal of Antibiotics
|September 23, 2018
PubMed

Insights

The rise in invasive fungal infections necessitates new antifungal drugs due to resistance and side effects. This review explores advances in antifungal therapy and novel strategies targeting new pathways for effective treatments.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Increasing incidence of invasive fungal infections, particularly in immunocompromised individuals.
  • Limitations of current antifungal drugs, including drug resistance, toxicity, and adverse effects.
  • Urgent need for novel antifungal agents to address treatment challenges.

Purpose of the Study:

  • To review advancements in traditional antifungal therapy.
  • To provide an overview of emerging strategies for treating fungal infections.
  • To highlight potential new targets for antifungal drug development.

Main Methods:

  • Literature review of recent research on antifungal therapies.
  • Analysis of traditional and novel approaches to combating fungal infections.
  • Identification of new therapeutic targets based on current scientific literature.

Main Results:

  • Traditional antifungal therapies face significant challenges with drug resistance and toxicity.
  • Novel strategies are being developed to overcome limitations of existing treatments.
  • Several new molecular targets show promise for the development of next-generation antifungal agents.

Conclusions:

  • Development of novel antifungal agents is crucial to combat rising fungal infections.
  • Exploring new targets is essential for creating more effective and safer antifungal drugs.
  • Advances in understanding fungal biology offer new avenues for therapeutic intervention.

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