Related Experiment Video
Updated: May 11, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Structure Elucidation of Two New Sesquiterpenoids From Streptomyces argenteolus Isolated From Pantholops hodgsoni
Dan Zheng1, Ting Zhou1, Yu Mu1
1Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, China.
Abstract:
Two new sesquiterpenoids, neopinguisane-2β,5β-diol (1) (pinguisane-type) and isoseiricardine B (2) (seiricardine-type), along with two known compounds, pentalenic acid (3) and nakienone C (4), were isolated from the culture broth of Streptomyces argenteolus derived from Pantholops hodgsoni feces. Structures of new compounds 1 and 2 were elucidated through comprehensive analysis of 1D and 2D NMR spectroscopic data. The stereochemistry at C-10 of compound 2 could not be determined due to insufficient sample quantity. This study represents the first reported isolation of both pinguisane-type and seiricardine-type sesquiterpenoids from Streptomyces species. In addition, the antimicrobial activities of all isolated compounds were evaluated.
Related Concept Videos
Differential Staining Technique
Special Staining Techniques

