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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
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Related Experiment Video

Updated: Feb 5, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine and cluster headache - the common link.

Anne Luise Vollesen1, Silvia Benemei2, Francesca Cortese3

  • 1Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

The Journal of Headache and Pain
|September 23, 2018
PubMed
Summary
This summary is machine-generated.

Migraine and cluster headache share triggers and treatments, possibly due to the trigeminovascular system. Further research into these shared pathways may reveal new treatments for both headache disorders.

Keywords:
Anti-CGRP (receptor) monoclonal antibodies – mAbsCalcitonin gene-related peptide (CGRP)Cluster headacheHypothalamusMigraineNeuromodulationTrigeminovascular system

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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Migraine and cluster headache are distinct primary headache disorders.
  • Both conditions share clinical features like unilateral pain and sensitivity to certain triggers.
  • Shared responses to treatments such as triptans, neuromodulation, and anti-CGRP therapies are noted.

Purpose of the Study:

  • To review and compare the similarities and differences between migraine and cluster headache.
  • To explore potential common pathophysiological mechanisms, particularly the trigeminovascular system.
  • To identify how understanding shared pathways can inform future therapeutic strategies.

Main Methods:

  • Literature review of past and current research on migraine and cluster headache.
  • Comparative analysis of clinical phenotypes, heritability, and pathophysiology.
  • Examination of neuroimaging findings and treatment responses.

Main Results:

  • Identified shared triggers (glyceryl trinitrate, histamine, CGRP) and responses (triptans, neuromodulation, anti-CGRP antibodies).
  • Highlighted the trigeminovascular system as a potential common pathway.
  • Detailed similarities and differences in various aspects including phenotype, genetics, and imaging.

Conclusions:

  • The trigeminovascular system is a likely common pathophysiological link between migraine and cluster headache.
  • Shared pathways offer a promising avenue for developing novel treatments beneficial for both patient groups.
  • Continued investigation into these commonalities is crucial for advancing headache disorder management.