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Early-onset dementia, leukoencephalopathy and brain calcifications: a clinical, imaging and pathological comparison

C Coomans1, A Sieben2,3, M Lammens3,4,5

  • 1Department of Neurology, Ghent University Hospital, Ghent, Belgium. carolinecoomans@hotmail.com.

Acta Neurologica Belgica
|September 23, 2018
PubMed

Insights

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALLD) and Nasu Hakola disease (NHD) are rare white matter diseases. Comparing three cases revealed novel mutations, advancing understanding of these progressive neurodegenerative conditions.

Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Background:

  • Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALLD) and Nasu Hakola disease (NHD) are underrecognized progressive white matter diseases.
  • Both conditions can manifest with early-onset dementia, leukoencephalopathy, and cerebral calcifications.

Keywords:
ALSPBrain calcificationsLeukoencephalopathyNasu HakolaPLOSL

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