[Inoperable non-small cell bronchopulmonary cancers. Results of ambulatory polychemotherapy including cisplatin]

Between October, 1981 and October, 1983, 57 subjects with inoperable non small-cell carcinoma of the lung (localized in 37, metastatic in 20) were treated as out-patients, after oral rehydration, with a multiple chemotherapy regimen which included Cisplatinum, Doxorubicin, Vincristine and Lomustine. No severe haematological or renal reaction was observed. After 2 courses 23 patients were responders (complete, or partial, or minor response), 2 of them with complete response. Patients with localized tumour had complementary radiotherapy, while chemotherapy was pursued in responsive patients with metastasis. Median survival was 9 months in responders and 5 months in non-responders. Thus, chemotherapy including Cisplatinum in medium doses (80 ms/sq.m) can be given to out-patients without risk of renal damage. The results obtained in this study are comparable to those of studies performed with other drug combinations including Cisplatinum.