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Intrahepatic sarcomatoid cholangiocarcinoma.
Sara Sintra1, Rui Costa2, Carlos Filipe1
1Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
BMJ Case Reports
|September 24, 2018
Summary
Sarcomatoid cholangiocarcinoma (CCC) is an extremely rare liver cancer. Immunohistochemistry is crucial for diagnosing this aggressive tumor, as highlighted by a recent case report.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Sarcomatoid carcinoma is a rare tumor with both epithelial and mesenchymal cells.
- Sarcomatoid cholangiocarcinoma (CCC) is an exceptionally rare primary liver cancer.
Observation:
- A case of an elderly male patient with head trauma presented with cerebral metastasis.
- Abdominal CT revealed a large (10x8x9 cm) hypodense liver mass in segments VII and VIII with peripheral enhancement.
Findings:
- Histological and immunohistochemical examination confirmed a malignant neoplasm with carcinomatous and sarcomatous components.
- Tumor cells showed positive expression for cytokeratin and vimentin antibodies.
- The patient was diagnosed with advanced intrahepatic sarcomatoid CCC and died 45 days post-diagnosis.
Implications:
- This case underscores the diagnostic challenge of sarcomatoid cholangiocarcinoma.
- Immunohistochemistry is vital for accurate diagnosis of rare liver tumors.
- Early diagnosis and understanding of aggressive tumor biology are critical.
