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Updated: Feb 4, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Comparative study of adjuvants for allergen-specific immunotherapy in a murine model
María Vázquez de la Torre1, Maria Luisa Baeza2,3,4, Laura Nájera5
1Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.
Aim:
To compare the immunological and clinical changes induced by allergen-specific immunotherapy (AIT) using different adjuvants.
Materials & Methods:
Olea europaea pollen-sensitized mice were treated with olea plus aluminum hydroxide, calcium phosphate, monophosphoryl lipid A (MPL) or immunostimulatory sequences (ISS).
Results:
Aluminum hydroxide seems to drive initially to a Th2-type response. Bacteria-derived adjuvants (MPL and ISS) skew the immune response toward Th1 and Treg pathways. Specific-IgE production was lower after AIT with MPL and ISS. Moreover, IgG2a production significantly increased in ISS-treated mice. Bacteria-derived adjuvants also improved the Th1 cytokine response due to IFN-γ higher secretion. In addition, they improved bronchial hyper-reactivity and lung inflammation.
Conclusion:
Bacteria-derived adjuvants may enhance the efficacy of AIT.
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