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Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
Published on: July 25, 2017
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Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues
Najate Benhra1, Lara Barrio1, Mariana Muzzopappa1
1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, Barcelona 08028, Spain.
Developmental Cell
|September 25, 2018
Summary
Chromosomal instability (CIN), characterized by changes in chromosome number, drives rapid cell invasion in a Drosophila model. This suggests that aneuploidy itself can promote cancer metastasis.
Area of Science:
- Cell Biology
- Genetics
- Cancer Research
Background:
- High metastatic activity in carcinomas is often linked to chromosomal instability (CIN).
- The precise role of CIN in promoting cancer cell invasiveness is not fully understood.
Purpose of the Study:
- To investigate the role of chromosomal instability (CIN) in driving invasive behavior.
- To elucidate the molecular mechanisms underlying CIN-induced cell invasion.
Main Methods:
- Utilized an epithelial cell model in Drosophila.
- Analyzed cellular behaviors including delamination, protrusion formation, and tissue invasion.
- Investigated the involvement of non-muscle Myosin II, Rho kinase, EGF/Spitz ligand, and MAPK pathways (Fos, Capicua).
Main Results:
- CIN promotes rapid and general invasive behavior in epithelial cells.
- Aneuploid cells exhibit delamination, cellular protrusions, and membrane blebbing.
- Invasion is regulated by non-muscle Myosin II activation and EGF/Spitz signaling.
- Fos and Capicua pathways are crucial for CIN-induced aneuploid cell invasion.
Conclusions:
- Chromosomal instability directly drives invasive cell behavior.
- The production of unbalanced karyotypes (aneuploidy) is a significant contributor to CIN-induced metastatic progression.
Keywords:
CapicuaDrosophilaEGFRFosJNKMyosin IIblebbingcell invasionchromosomal instabilitygene dosage imbalanceMore Related Videos
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