CYP1B1: A Context-Dependent Regulator of Metabolism in Diabetic Kidney Disease
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Dazhou Zeng1, Harvest F Gu1, Xiaohui Jing1
1Laboratory of Molecular Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Article Highlights:
This study systematically dissects the regulatory role of CYP1B1 in the pathogenesis of diabetic kidney disease (DKD). CYP1B1 participates in the progression of DKD by mediating the metabolism of arachidonic acid, retinoic acid, and estradiol, as well as the process of ferroptosis. Its 4-OHE2 quinone metabolites and proferroptotic effect promote renal injury, while it is associated with the maintenance of renoprotective signaling. The net effect of CYP1B1 is regulated by substrate type, cell type, and disease stage, and it can serve as an epigenetic marker and gut-kidney axis mediator in DKD.
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