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A liposome preparation based on β-CD-LPC molecule and its application as drug-delivery system
Anran Cai1, Chunhua Wang1,2, Miaomiao Yan3
1Department of Pharmacy, Binzhou Medical University, Yantai, 264003, PR China.
Aim:
The β-CD-LPC molecule was synthesized based on the conjugation of LPC and β-CD molecules and it could self-assemble into liposome which was used to encapsulate the Dox to form nanomedicine for the cancer therapy.
Materials & Methods:
The anticancer and antitumor effect of β-CD-LPC-Dox nanomedicine was studied with the vitro and vivo experimental methods.
Results:
The result showed that β-CD-LPC liposome had high Dox drug-loading rate and a good sustained-release effect. Cell experiment showed that the β-CD-LPC-Dox nanomedicine could effectively induce cancer cell apoptosis and in vivo experiments showed that β-CD-LPC-Dox liposome could effectively inhibit tumor growth and had an effective anticancer activity with lower biotoxicity.
Conclusion:
The β-CD-LPC-Dox nanomedicine could be applied as a candidate drug to therapy the cancer.
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