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In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model
Aline da Graça Sampaio1,2, Aline Vidal Lacerda Gontijo3, Helena Marcolla Araujo2
1Department of Environmental Engineering and Oral Biopathology Graduate Program, São José dos Campos Institute of Science and Technology, Universidade Estadual Paulista (UNESP), São José dos Campos, Brazil.
Abstract:
The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.
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