Related Experiment Video
Updated: Feb 4, 2026

Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Effect of age on pulpal blood flow in human teeth during orthodontic movement
Seyda Ersahan1, Fidan A Sabuncuoglu2
1Department of Endodontics, Faculty of Dentistry, Istanbul Medipol University.
Abstract:
We aimed to assess the relationship between age, pulpal blood flow (PBF), and orthodontic treatment outcomes. Decreased blood supply to pulp cells commonly occurs with age and can change the response of pulp to orthodontic tooth movement. This study was conducted in 28 human subjects divided into 2 groups according to age. A laser Doppler flowmeter was used to record blood flow to the teeth prior to and during the course of orthodontic treatment (days 1, 3, and 7; week 3; and month 1). Data were analyzed using Wilcoxon signed-rank and Mann-Whitney U tests. Mean PBF values were significantly higher in the young group compared to the old group at all time points (P < 0.001). The decreased PBF in response to tooth movement was more severe in the old group and was also of longer duration. Pulp in younger patients had significantly higher blood flow values compared to that in older patients at baseline and throughout the course of the study.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Blood Flow
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Applications of Integration to Find Blood Flow
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Anatomical Movements
Here are some common anatomical movements:
Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist,...

