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Updated: Feb 4, 2026
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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
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Spindle cell melanoma: Incidence and survival, 1973-2017
Zhe Xu1, Ping Shi1, Feiluore Yibulayin2,3
1Department of Stomatology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong 518110, P.R. China.
Oncology Letters
|September 26, 2018
Summary
Spindle cell melanoma (SCM) is rare but characterized by specific demographics and prognostic factors. Age, ethnicity, and tumor stage significantly impact survival outcomes for SCM patients.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Spindle cell melanoma (SCM) is a rare and understudied subtype of melanoma.
- Understanding SCM's characteristics is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the incidence, demographics, clinical features, and survival of SCM.
- To identify independent prognostic factors for SCM.
Main Methods:
- Analysis of 4761 SCM cases from the Surveillance, Epidemiology, and End Results (SEER) Program (1973-2017).
- Statistical analysis including overall survival (OS) and disease-specific survival (DSS) rates.
- Multivariate Cox regression analysis for prognostic factor identification.
Main Results:
- SCM is most common in Caucasian males aged 60-80 years.
- Significant survival differences were observed based on age, sex, ethnicity, tumor stage (TNM), and AJCC/SEER stages.
- Advanced age (>66 years), T3+T4 stage, positive N stage, and distant metastasis were linked to poorer survival.
Conclusions:
- SCM exhibits distinct demographic and clinical features.
- Patient age, ethnicity, T stage, N stage, and SEER historic stage are independent prognostic factors for SCM survival.
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