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Incidence of methicillin resistant Staphylococcus aureus (MRSA) in burn intensive care unit: a systematic review

Tahir Mehmood Khan1, Yee Leng Kok2, Allah Bukhsh3

  • 1Assoc Prof, Dr, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia, Asian Centre for Evidence Synthesis in Population, Implementation and Clinical Outcomes (PICO), Health and Well-being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia, Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences (UVAS), Outfall road, Lahore, Pakistan.

Germs
|September 26, 2018
PubMed
Abstract

Insights

Burn intensive care unit patients face a high risk of methicillin-resistant Staphylococcus aureus (MRSA) infections. This review highlights the incidence and antibiotic resistance of MRSA in burn ICUs, emphasizing the need for improved hygiene and wound care.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Burn patients in intensive care units (ICUs) are highly susceptible to nosocomial infections.
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in this vulnerable population.
  • Understanding MRSA incidence and resistance patterns is crucial for effective patient management.

Purpose of the Study:

  • To systematically review and estimate the incidence of MRSA among burn patients admitted to ICUs.
  • To analyze the antibiotic resistance profile of MRSA strains isolated from burn ICU patients.
  • To provide insights into the prevalence and characteristics of MRSA in burn care settings.

Main Methods:

  • A comprehensive systematic literature search was conducted across five electronic databases.
  • The search was limited to articles published between January 1, 2000, and August 31, 2017.
  • A meta-analysis was performed on 21 selected studies after screening 481 articles.

Main Results:

  • The meta-analysis indicated a 55.0% higher risk of MRSA isolates in burn ICUs (OR 0.55, 95% CI 0.32-0.94).
  • Findings underscore the elevated risk of MRSA colonization or infection in burn patients within ICUs.
  • Urgent implementation of timely testing, stringent hygiene, and appropriate wound care is recommended.

Conclusions:

  • Further research is necessary to elucidate specific risk factors for MRSA infections in burn patients.
  • Development of novel antimicrobial agents is essential to combat emerging MRSA resistance.
  • Enhanced surveillance and infection control strategies are vital in burn ICUs.
Keywords:
Burnantibiotic resistantmeta-analysismethicillin resistant Staphylococcus aureus (MRSA)systematic review

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