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Updated: Feb 4, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
ARF-NRF2: A new checkpoint for oxidative stress responses?
Delin Chen1, Omid Tavana1, Wei Gu1
1Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons of Columbia University, 1130 St. Nicholas Avenue, New York, New York.
Abstract:
NRF2 (nuclear factor erythroid 2-related factor 2) is a transcription factor which plays a major role in oxidative stress responses by regulating antioxidant gene expression. We have recently identified the ARF tumor suppressor as a key regulator of NRF2. ARF can significantly inhibit NRF2 transcriptional activities, and the ARF-NRF2 interaction may function as a novel checkpoint for oxidative stress responses.
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