Related Experiment Video
Updated: Feb 4, 2026
06:54
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
14.4K
PSPC1 potentiates TGF-β-dependent metastatic dissemination
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Molecular & Cellular Oncology
|September 26, 2018
Summary
Paraspeckle component 1 (PSPC1) drives cancer metastasis by activating key processes like epithelial-to-mesenchymal transition (EMT) and stemness. This finding reveals PSPC1 as a crucial regulator in malignant tumor progression.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Metastatic tumor progression is driven by oncogenic regulators.
- The specific cellular factors controlling metastatic reprogramming are not fully understood.
Purpose of the Study:
- To identify key cellular determinants of metastatic reprogramming.
- To investigate the role of identified genes in activating pro-metastatic pathways.
Main Methods:
- Identification of aberrant prognostic cancer genes.
- Analysis of the function of identified genes in cancer progression.
Main Results:
- Paraspeckle component 1 (PSPC1) was identified as a critical gene.
- PSPC1 acts as a master activator of metastatic reprogramming.
- PSPC1 promotes epithelial-to-mesenchymal transition (EMT), stemness, and the TGF-β1 pathway.
Conclusions:
- PSPC1 is a key regulator in the metastatic reprogramming of malignant tumors.
- Targeting PSPC1 may offer a therapeutic strategy against cancer metastasis.
Related Concept Videos
01:16TGF - β Signaling Pathway
10.5K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.5K
01:21Frequency-dependent Selection
24.1K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.1K
02:58Cell Potential and Free Energy
46.6K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.6K
02:55Temperature Dependence on Reaction Rate
89.1K
The Collision Theory
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
89.1K
00:52Potential Energy
42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
01:17Drug Dependence
1.7K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.7K