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Navigating Systemic Therapy in Advanced Thyroid Carcinoma: From Standard of Care to Personalized Therapy and Beyond

Sarika N Rao1,2, Maria E Cabanillas3

  • 1MedStar Washington Hospital Center, Washington, DC.

Journal of the Endocrine Society
|September 26, 2018
PubMed

Insights

Thyroid cancer outcomes are favorable, but advanced or recurrent cases require targeted therapy. This review discusses when and how to initiate kinase inhibitor treatments for better patient prognosis.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Thyroid cancer generally has a good prognosis with standard treatment, except for anaplastic thyroid cancer.
  • Persistent, recurrent, or metastatic thyroid cancer presents a significant challenge with a poorer prognosis.

Purpose of the Study:

  • To discuss the optimal timing and strategy for initiating targeted therapy in advanced thyroid cancer.
  • To provide guidance on the clinical application of kinase inhibitors for thyroid cancer management.

Main Methods:

  • Review of current clinical practice and emerging data on targeted therapies for thyroid cancer.
  • Discussion of approved kinase inhibitor regimens and those in development.

Main Results:

  • Five drug regimens targeting kinase pathways are currently approved for differentiated, medullary, and anaplastic thyroid cancer.
  • Numerous additional targeted therapy options are under investigation and development.

Conclusions:

  • While standard therapy is effective for most thyroid cancers, targeted therapies are crucial for advanced or refractory disease.
  • Deciding when and how to implement kinase inhibitor therapy remains a key clinical dilemma requiring careful consideration.
Keywords:
BRAF inhibitorsanaplastic thyroid cancerdifferentiated thyroid cancerimmunotherapykinase inhibitorsmedullary thyroid cancer

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