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Identification of botanicals with potential therapeutic use against methicillin-resistant Staphylococcus aureus

Johanne Gerstel1, Tiffany Turner1, Guillermo Ruiz1

  • 1Center for Intergrative Naturopathic Research, Southwest College of Naturopathic Medicine, Tempe, Arizona.

Phytotherapy Research : PTR
|September 26, 2018
PubMed

Insights

Botanical extracts show promise as an alternative treatment for Staphylococcus aureus and antibiotic-resistant strains like MRSA. Thirteen effective plant extracts were identified, offering potential new therapies against challenging bacterial infections.

Area of Science:

  • Microbiology
  • Pharmacology
  • Ethnobotany

Background:

  • Staphylococcus aureus is a significant opportunistic pathogen.
  • Increasing antibiotic resistance, including Methicillin-Resistant Staphylococcus aureus (MRSA), necessitates novel therapeutic strategies.
  • Over-reliance on conventional antibiotics has driven the evolution of multidrug-resistant (MDR) strains.

Purpose of the Study:

  • To evaluate the efficacy of botanical extracts against Staphylococcus aureus and its antibiotic-resistant variants.
  • To identify plant-derived compounds with antimicrobial activity as potential alternatives to conventional antibiotics.
  • To compare the potency of different botanical extracts against susceptible and resistant bacterial strains.

Main Methods:

  • Minimum Inhibitory Concentration (MIC) assay for initial screening of botanical extracts.
  • Temporal growth curve analysis to quantify bacterial inhibition by extracts.
  • Categorization of botanicals based on efficacy (mild, moderate, highly efficacious).

Main Results:

  • Thirteen botanical extracts demonstrated varying levels of antimicrobial activity against Staphylococcus aureus, penicillin/methicillin-resistant S. aureus (PenR), and MDR strains.
  • Efficacy was correlated with the concentration of the extract required for bacterial growth inhibition.
  • Botanicals were classified into mild, moderate, and highly efficacious groups.

Conclusions:

  • Botanical extracts represent a viable alternative therapeutic approach for combating Staphylococcus aureus infections.
  • Specific plant-derived compounds show significant potential in addressing antibiotic resistance, including MRSA and MDR strains.
  • Further research into these identified botanicals could lead to the development of new antimicrobial agents.
Keywords:
MRSAStaphylococcus aureusantibiotic resistancebotanicaltincture

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