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Updated: Feb 4, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
Metal-Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold
Jun Ohata1, Samuel C Martin1, Zachary T Ball1
1Department of Chemistry, Rice University, 6100 Main, Houston, TX, 77005, USA.
Abstract:
Selective modification of natural proteins is a daunting methodological challenge and a stringent test of selectivity and reaction scope. There is a continued need for new reactivity and new selectivity concepts. Transition metals exhibit a wealth of unique reactivity that is orthogonal to biological reactions and processes. As such, metal-based methods play an increasingly important role in bioconjugation. This Review examines metal-based methods as well as their reactivity and selectivity for the functionalization of natural proteins and peptides.
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