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Recent developments in pleurodesis for malignant pleural disease
Julien Guinde1, Samer Georges1,2, Valerian Bourinet1
1Department of Thoracic Oncology, Pleural Diseases and Interventional Pulmonology, Hôpital Nord, Marseille, France.
The Clinical Respiratory Journal
|September 26, 2018
Summary
This review explores recent advances in pleurodesis for managing malignant pleural effusion (MPE). Talc pleurodesis is effective, and personalized management targeting intrapleural molecules is the future for recurrent MPE.
Area of Science:
- Pulmonology
- Oncology
- Thoracic Surgery
Background:
- Metastatic pleural effusion (MPE) is a common cause of pleural effusion.
- Management focuses on symptom palliation and improving quality of life.
- Recurrent MPE often requires interventions like ambulatory pleural drainage or pleurodesis.
Purpose of the Study:
- To review recent evidence-based advances in pleurodesis for managing MPE.
- To highlight current therapeutic strategies and future directions.
Main Methods:
- Systematic literature search of PubMed for articles published after January 2010.
- Cross-referencing and selection of relevant articles focusing on MPE pleurodesis.
- Analysis of 106 selected abstracts for review.
Main Results:
- Pleurodesis is a key intervention for recurrent MPE.
- Talc demonstrates efficacy as a sclerosing agent, potentially combined with indwelling pleural catheters.
- Patient factors like life expectancy and preferences are crucial in treatment decisions.
Conclusions:
- Treatment for recurrent MPE should be individualized.
- Talc pleurodesis, alone or with indwelling pleural catheters, is a promising strategy.
- Further research into MPE pathophysiology is needed for personalized management targeting intrapleural molecules.
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