Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catalysis02:50

Catalysis

30.6K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
30.6K
Replication in Eukaryotes02:31

Replication in Eukaryotes

205.1K
Overview
205.1K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

18.8K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.8K
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

27.1K
RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
27.1K
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

38.6K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.6K
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

10.7K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
10.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amorfrutin-A, a membrane-targeting phytochemical active against multidrug-resistant Staphylococcus aureus: In vitro and in vivo activity and mechanism of action.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Correction: The different affinity of the two metal-binding sites of human ferroportin drives outward directionality of transport.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2025
Same author

Discovery of new neutrophil elastase inhibitors through Meloidae genome and transcriptome analyses.

Bioorganic chemistry·2025
Same author

Structural Instability of Human Serum Albumin during Microparticles Synthesis.

ACS applied bio materials·2025
Same author

Proton-linked effects on the axial coordination in ferric and ferrous horse heart cytochrome c.

Protein science : a publication of the Protein Society·2025
Same author

Horse heart mini- and full length-myoglobin: pH effects on CO binding.

Journal of inorganic biochemistry·2025
Same journal

ALKBH4 Promotes Osteogenesis via Epigenetic Regulation of BMP2-Wnt/β-Catenin Signaling in Cervical Spine OPLL.

IUBMB life·2026
Same journal

Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes.

IUBMB life·2026
Same journal

Mechanism of PCSK9-Mediated Macrophage Activation via the CAP1/NF-κB Pathway in CAWS-Induced Kawasaki Disease Vasculitis.

IUBMB life·2026
Same journal

Hormesis and the Golden Ratio: Toward a Universal Estimator of Adaptive Capacity.

IUBMB life·2026
Same journal

MicroRNAs in HPV-Associated Carcinogenesis: Potential Biomarkers in Oropharyngeal and Cervical Cancers.

IUBMB life·2026
Same journal

PGAM1 Orchestrates Cell Cycle Progression, Glycolytic Reprogramming, and Immunosuppressive Microenvironment in Triple-Negative Breast Cancer.

IUBMB life·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals
07:24

Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals

Published on: April 14, 2020

18.6K

Lanthanides-based catalysis in eukaryotes.

Giovanna De Simone1, Fabio Polticelli1,2, Silvio Aime3

  • 1Department of Sciences, Roma Tre University, Roma, Italy.

IUBMB Life
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

Cerium (Ce3+)-dependent methanol dehydrogenases (MDHs) are found in higher organisms, not just prokaryotes. These enzymes, identified in diverse species including humans, likely resulted from multiple gene transfers from bacteria.

Keywords:
Ca2+-dependent methanol dehydrogenaseCe3+-dependent methanol dehydrogenaseevolutionlanthanides-based catalysislateral gene transferstructure

More Related Videos

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
10:10

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

Published on: July 28, 2018

6.9K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.4K

Related Experiment Videos

Last Updated: Feb 4, 2026

Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals
07:24

Hyperspectral Imaging as a Tool to Study Optical Anisotropy in Lanthanide-Based Molecular Single Crystals

Published on: April 14, 2020

18.6K
Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
10:10

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

Published on: July 28, 2018

6.9K
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

15.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Rare earth elements, like cerium (Ce3+), are crucial in technology and medicine.
  • Biochemically, Ce3+ can substitute for calcium (Ca2+) in metalloenzymes, particularly methanol dehydrogenases (MDHs).
  • Previously, Ce3+-dependent MDHs were exclusively identified in Archaea and Bacteria.

Purpose of the Study:

  • To investigate the presence of Ce3+-dependent MDHs in higher organisms.
  • To explore the evolutionary origins of these enzymes in eukaryotes.

Main Methods:

  • Bioinformatic analysis of protein sequence databases.
  • Identification of Ce3+-dependent MDHs in various species.
  • Analysis of gene structure (intron presence/absence).

Main Results:

  • Ce3+-dependent MDHs were identified in the parasite Plasmodium yoelii yoelii, the spider Nephila clavipes, the Tibetan antelope Pantholops hodgsonii, and Homo sapiens.
  • These eukaryotic MDHs are encoded by intronless genes.
  • Conserved residues suggest these enzymes belong to the known Ce3+-dependent MDH family.

Conclusions:

  • Ce3+-dependent MDHs are present in higher eukaryotes, challenging previous assumptions.
  • The discovery indicates multiple, independent lateral gene transfer events from prokaryotes to eukaryotes.
  • These findings expand the known distribution and evolutionary history of Ce3+-dependent MDHs.