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Myomaker and Myomerger: It Takes Two to Make One
Nandini N Margam1, Roy Duncan2
1Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H4R2, Canada.
Developmental Cell
|September 26, 2018
Abstract:
Muscle-forming myotubes are formed from the cell-cell fusion of myoblasts. In this issue of Developmental Cell, Leikina et al. (2018) provide compelling evidence that myoblast fusion is dependent on a two-component membrane fusion complex of Myomaker and Myomerger, which function in hemifusion and pore formation activity, respectively.
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